Bruno Lage's men face the London side for a third game in a row but will be grateful to be back at Molineux on Saturday after back-to-back defeats in the capital.
As the search for European places intensifies, nothing but a win will be enough for Wolves, as they are five points behind sixth-placed Arsenal, who also have two games in hand.
The Visiting Eagles, managed by Patrick Vieira, travel to Wolverhampton after their midweek FA Cup last-16 win against Stoke City.
Palace sit comfortably in the mid-table but come away with a combined league-high record of 12 draws this season.
What time is Wolves vs Crystal Palace?
Wolves vs Crystal Palace is one of five kick-offs in the Premier League starting at 5 p.m. on Saturday.
Where to follow Wolves vs Crystal Palace
Since it started at 3 pm, the match will not be shown live in the UK.
Fans can follow the match blog on the Express & Star, but there will also be match commentary on BBC Radio Wolverhampton.
Team news
Pedro Neto made his third substitute appearance of the season at West Ham on Sunday, and Bruno Legge may be tempted to bring him into the starting line-up to shake things up further down the line.
Crystal Palace comes into the game without any injury concerns.
Next fixture
Next up for the Wolves is a visit from Roy Hodgson to Watford.
The match was originally scheduled to take place on Boxing Day, but after being postponed due to COVID, the match has been rescheduled for Thursday, March 10 at 7.30 pm.