Manchester United's fixture against Brentford has been postponed after the COVID-19 outbreak forced the club to close its training ground.
United closed their Carrington training base on Monday after a PCR test confirmed positive coronavirus cases.
A small number of players and staff were sent home on Sunday after routine lateral flow tests came back positive. The club's academy, training in a separate bubble, was allowed to continue.
"Due to the extraordinary circumstances of the ongoing COVID-19 outbreak within Manchester United's squad, the decision was taken following guidance from medical advisors," the league said in a statement.
"First team operations at the club's Carrington training complex were closed today to help control the outbreak among players and staff and reduce the risk of further infection."
United were to travel to play Brentford in London on Tuesday night, with the match now to be rescheduled to a later date.
On Monday, a separate Premier League statement reported a record high in COVID positives in the league at 42 and said they were returning to their emergency measures for all teams.
The statement read: "Everyone's safety is a priority and the Premier League is taking all precautionary measures in light of the recent increase in COVID-19 cases across the country. The league is back on its emergency measures, and will increase the frequency of players." and of both lateral flow and PCR COVID-19 tests of staff. The league can confirm today that 3,805 players and club staff were tested for COVID-19 between Monday 6 December and Sunday 12 December. Of these 42 new Positive cases were reported."
Tottenham Hotspur's clash with Brighton & Hove Albion last week was postponed by the Premier League following a serious coronavirus outbreak among Antonio Conte's squad.